Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study.

OBJECTIVE To investigate the distribution of lobar microbleeds over the different lobes, taking into account lobar volume and clustering effects of multiple microbleeds. DESIGN Population-based, cross-sectional analysis. SETTING The Rotterdam Scan Study. PARTICIPANTS A total of 198 persons (age range, 61-95 years) with lobar microbleeds. MAIN OUTCOME MEASURES Distribution of microbleeds over different lobes. RESULTS We found that lobar cerebral microbleeds occurred significantly more often in the temporal lobe, a region known to be more affected in cerebral amyloid angiopathy. CONCLUSION This study corroborates the presumed association of lobar microbleeds with cerebral amyloid angiopathy.